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Title:
Asymmetric Organic Synthesis with Enzymes |
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Division: General Biochemistry / John Wiley & Son / English |
Author/Editor: Vicente Gotor (Editor), Ignacio Alfonso (Editor), Eduardo García-Urdi Star:  |
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ISBN: 3527318259 |
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Introduce Date: 2008年07月17日18:36 , Release Date: 2008年07月17日18:38 |
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Introducer: Metalcarbene , Rate: 29/428 |
| Format: pdf(editorial) Download |
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| Appraiser: cooldog | Grade: +1 | Reason: ( 这个东东下了两节就让注册:( ) | | | Appraiser: cooldog | Grade: +5 | Reason: ( 正在找这本书,非常感谢!:) ) | | | Appraiser: 明月飞光 | Grade: +5 | Reason: ( 昨天看到一本，要2000积分下不了，只有自己去下。还是老大好。感谢，我收下了。 ) | | | Appraiser: rbhuang | Grade: +1 | Reason: ( 这本书很差 ) | | | Appraiser: smale | Grade: +1 | Reason: ( 这本书很棒 ) | |
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| Description: |
Asymmetric Organic Synthesis with Enzymes
Vicente Gotor (Editor), Ignacio Alfonso (Editor), Eduardo García-Urdiales (Editor)
ISBN: 978-3-527-31825-4
Hardcover
340 pages
April 2008
Wiley List Price: US $215.00
Perfect for biochemists, synthetic and organic chemists, this book covers all important reactions, including C-C coupling reactions, oxidation reactions and many more.
Divided into two parts, the first section on methodology presents new innovative methods for enzymatic catalysis optimization, including such new trends as medium engineering, directed evolution and computer-aided prediction of enantioselectivity. The second and main section deals with applications to synthesis, showing important reaction types and their applications. Only those reactions with very high selectivity are presented, allowing readers to improve their own reaction yields.
Vicente Gotor assumed his current position as Professor of Organic Chemistry at the University of Oviedo in 1982. His research fields include the areas of Heterocyclic and Bioorganic Chemistry. Specific areas of his research interest are enzymatic amidation reactions with hydrolases, enzymatic chemoselective transformations on natural products, biotransformations with oxynitrilases and oxidoreductases, and chiral recognition with azamacrocycles. He was Vice-chancellor of Research of Oviedo University for four years until June 2000. At present, he is the leader of Bioorganic group in the Chemistry Faculty of Oviedo University and Head of Department of Organic and Inorganic Chemistry. He has published more of 240 papers, is director of 40 Doctoral Thesis and coauthor of 10 patents.
Ignacio Alfonso completed his PhD in 1999 at the University of Oviedo, obtaining the PhD extraordinary award. During his doctoral studies, he spent a short period of time at the University of Strasbourg working under the supervision of Profs. Bernard Dietrich and Nobel Prize Winner Jean-Marie Lehn. After finishing his PhD, he moved to The Scripps Research Institute in La Jolla, California, as a postdoctoral fellow with Prof. M. Reza Ghadiri. Since 2004, he is researcher at the University Jaume I in Castellón, Spain. His research interests are bioorganic and supramolecular chemistry, biosensing, molecular recognition as well as natural and biomimetic catalytic systems.
Eduardo García-Urdiales graduated in Chemistry in 1996 at the University of Oviedo. He joined Prof. Gotor's group where he performed his PhD. After having finished it in 2001, he moved to Solvay Pharmaceuticals GmbH in Hannover (Germany) as a postdoctoral fellow in the Computer Aided Drug Design unit, where he stayed for two years (2001-2003). Then, he moved back to Oviedo and since 2005 he is working at the Russell Group at EMBL Heidelberg (Germany). His research interests are focussed on the study of protein-ligand interactions by means of computational methods.
Front Matter (p I-XIV)
Summary | Full Text: PDF (Size: 151K)
Part I: Methodology
Chapter 1:
Medium Engineering (p 1-20)
Giacomo Carrea, Sergio Riva
Summary | References | Full Text: PDF (Size: 153K)
Chapter 2:
Directed Evolution as a Means to Engineer Enantioselective Enzymes (p 21-63)
Manfred T. Reetz
Summary | References | Full Text: PDF (Size: 517K)
Chapter 3:
The Search for New Enzymes (p 65-85)
Jean-Louis Reymond, Wolfgang Streit
Summary | References | Full Text: PDF (Size: 227K)
Part II: Synthetic Applications
Chapter 4:
Dynamic Kinetic Resolutions (p 87-113)
Belén Martín-Matute, Jan-E. Bäckvall
Summary | References | Full Text: PDF (Size: 219K)
Chapter 5:
Deracemization and Enantioconvergent Processes (p 115-131)
Nicholas J. Turner
Summary | References | Full Text: PDF (Size: 182K)
Chapter 6:
Transesterification and Hydrolysis of Carboxylic Acid Derivatives, Alcohols, and Epoxides (p 133-169)
Robert Chênevert, Pierre Morin, Nicholas Pelchat
Summary | References | Full Text: PDF (Size: 332K)
Chapter 7:
Aminolysis and Ammonolysis of Carboxylic Acid Derivatives (p 171-191)
Vicente Gotor-Fernández, Vicente Gotor
Summary | References | Full Text: PDF (Size: 185K)
Chapter 8:
Enzymatic Reduction Reaction (p 193-228)
Kaoru Nakamura, Tomoko Matsuda
Summary | References | Full Text: PDF (Size: 388K)
Chapter 9:
Biooxidations in Chiral Synthesis (p 229-274)
Marko D. Mihovilovic, Dario A. Bianchi
Summary | References | Full Text: PDF (Size: 327K)
Chapter 10:
Aldolases: Enzymes for Making and Breaking CC Bonds (p 275-318)
Wolf-Dieter Fessner
Summary | References | Full Text: PDF (Size: 441K)
Index (p 319-325)
Summary | Full Text: PDF (Size: 60K)
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