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Title:
Vanadium - Chemistry, Biochemistry, Pharmacology and Practical Applications |
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Division: Bioinorganic Chem / CRC Press / English |
Author/Editor: Alan S. Tracey, Gail R. Willsky, Esther S. Takeuchi Star:  |
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ISBN: 1420046136 |
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Introduce Date: 2008年08月13日09:47 , Release Date: 2008年08月14日01:14 |
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Introducer: zhaojfyx , Rate: 0/80 |
| Format: pdf(editorial) Download |
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| Appraiser: ru0629 | Grade: +1 | Reason: ( 这本书太贵了! ) | | | Appraiser: hqzhang | Grade: +1 | Reason: ( good ) | |
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| Description: |
Publisher: CRC
Number Of Pages: 250
Publication Date: 2007-03-19
Written by leading authorities, this unique work examines the aqueous chemistry of vanadium. Focusing on the V(V) oxidation state, it highlights the use of 51V NMR spectroscopy. It covers reactions of vanadium with biologically important ligands such as amino acids, peptides, and sulfhydryl ligands. It reviews vanadium’s role in biological systems and pharmacological effects and addresses the importance of ligand electronic properties in determining speciation, coordination geometry, and heteroligand reactivity. It also describes recent advances in practical applications such as in the non-aqueous vanadium oxide bronze battery systems, which are particularly suited to medical applications.
Explores environmental influences, pharmacological applications, and technological uses of vanadium
Provides a detailed description of the vanadium battery
Compiles the results from research on the aqueous coordination reactions characterizing the vanadium(V) oxidation state
Details the application of NMR spectroscopy to the speciation of vanadium compounds
Describes recent advances in the applications of the lithium/silver vanadium oxide battery, particularly for medical applications
Explains signal transduction processes and related biology, biochemistry, and cell biology in a way that is accessible to chemists
The first comprehensive resource on the chemistry of vanadium, Vanadium: Chemistry, Biochemistry, Pharmacology, and Practical Applications has evolved from over a quarter century of research that concentrated on delineating the aqueous coordination reactions that characterize the vanadium(V) oxidation state. The authors distill information on biological processes needed to understand vanadium effects in biological systems and make this information accessible to a wide range of readers, including chemists without extensive biological training.
Building a hierarchy of complexity, the book provides a discussion of some basic principles of 51V NMR spectroscopy followed by a description of the self-condensation reactions of vanadate itself. The authors delineate reactions with simple monodentate ligands and then proceed to more complicated systems such as diols, a-hydroxy acids, amino acids, peptides, to name just a few. They revisit aspects of this sequence later, but first highlight the influence the electronic properties of ligands have on coordination and reactivity. They then compare and contrast the influences of ligands, particularly those of hydrogen peroxide and hydroxylamine, on heteroligand reactivity.
The book includes coverage of vanadium-dependent haloperoxidases and model systems, vanadium in the environment, and technological applications. It also briefly covers the catalytic reactions of peroxovanadate and haloperoxidase model compounds. It contains a discussion of the vanadium haloperoxidases and the biological and biochemical activities of vanadium(V) including potential pharmacological applications. The last chapters step outside these boundaries by introducing some aspects of the future of vanadium in nanotechnology, the recyclable redox battery, and the lithium/silver vanadium oxide battery.
Primary sources documented after each chapter minimize the need to search the literature, 80 illustrations provide structural information, reaction schemes, spectra, speciation diagrams, and biochemical schemes, and 22 tables present detailed information with references to primary sources. Packed with current and authoritative information, the book covers chemistry and bioinorganic vanadium chemistry in a broad and systematic manner that engenders comprehensive understanding.
Table of Contents
Chapter 1
Introduction
1.1 background. 1
1.1.1 Vanadium (V
1.1.2 Vanadium (II), (III), and (IV) References
Chapter 2
Vanadate Speciation 7
2.1 Techniques. 7
2.1.1 Vanadium-51 NMR Spectroscopy 8
2.1.2 pH-Dependence of Vanadium Chemical Shifts. 11
2.1.3 V 2-Dimensional NMR: Correlation and
Exchange Spectroscopies ........12
2.1.41H and13C NMR Spectroscopy .. ..13
2.1.517O NMR Spectroscopy .....14
2.1.6 NMR Spectroscopy in Lipophilic Solutions ........ .......15
2.2 Vanadate Self-Condensation Reactions ............ .....19
2.2.1 The Commonly Encountered Vanadates............................................19
2.2.2 Decavanadate......................................................................................25
2.3 Vanadium Atom Stoichiometry of Complexes ....
References.......... .................................27
Chapter 3 Monodentate Ligands of Vanadate ... .31
3.1 Alcohols and Phenols..... .........31
3.1.1 Primary, Secondary, and Tertiary Aliphatic Alcohols .......................31
3.1.2 Phenols ...............................................................................................33
3.2 Amines and Acids ........... ....33
3.2.1 Aliphatic and Aromatic Amines ........................................................33
3.2.2 Carboxylic Acids, Phosphate, Arsenate, and Sulfate ........................34
3.2.3 Sulfhydryl Ligands.............................................................................35
References....................... .................................35
Chapter 4Aqueous Reactions of Vanadate with Multidentate Ligands .37
4.1 Glycols,α-Hydroxycarboxylic Acids, and Dicarboxylic Acids
4.1.1 Glycols: Cyclohexane Diols, Carbohydrates, and Nucleosides
4.1.2α-Hydroxy Carboxylic Acids, Maltol................................................43
4.1.2.1 Heteroligand Complexes.....................................................47
4.1.3 Dicarboxylic Acids: Oxalic, Malonic, and Succinic Acids...............48
4.2 Hydroxamic Acids..................... ....................49
4.3 Thiolate-Containing Ligands ........ ...............51
4.3.1β-Mercaptoethanol and Dithiothreitol ...............................................51
4.3.2 Bis(2-thiolatoethyl)ether, Tris(2-thiolatoethyl)amine, and
Related Ligands......... ...............................53
4.3.3 Cysteine, Glutathione, Oxidized Glutathione, and Other
Disulfides.......... .......................53
4.4 Amino Alcohols and Related Ligands.................. .54
4.4.1 Bidentate Amino Alcohols and Diamines .........................................54
4.4.2 Polydentate Amino Alcohols: Diethanolamine and Derivatives
4.5 Amino Acids and Derivatives
4.5.1 Ethylene-N,N-Diacetic Acid and Similar Compounds
4.5.2 Pyridine Carboxylates, Pyridine Hydroxylates,
and Salicylate ......... ..........58
4.5.3 Amides ............. .......................61
4.6α-Amino Acids and Dipeptides ... ..61
4.6.1α-Amino Acids...................................................................................61
4.6.2 Dipeptides...........................................................................................62
4.7 Other Multidentate Ligands ............. .............72
References.............. ..............................74
Chapter 5Coordination of Vanadate by Hydrogen Peroxide
and Hydroxylamines ......... ..........................81
5.1 Hydrogen Peroxide ........... .....................82
5.2 Hydroxylamines ....... ................85
5.3 Coordination Geometry of Peroxo and Hydroxamido Vanadates.. 87
References............. ...............................95
Chapter 6 Reactions of Peroxovanadates ........ ...99
6.1 Heteroligand Reactions of Bisperoxovanadates ...... ....99
6.1.1 Complexation of Monodentate Heteroligands...................................99
6.1.2 Complexation of Oxobisperoxovanadate by Multidentate
Heteroligands .......... .....................104
6.2 Reactions of Monoperoxovanadates with Heteroligands
6.2.1 Complexation by Amino Acids, Picolinate,
and Dipeptides............ ...............106
6.2.2 Complexation by α -Hydroxycarboxylic Acids ...............................111
6.3 Oxygen Transfer Reactions of Peroxovanadates..... 114
6.3.1 Halide Oxidation ..............................................................................114
6.3.2 Sulfide Oxidation .............................................................................116
References................ ................................118
Chapter 7 Aqueous Reactions and NMR Spectroscopy of
Hydroxamidovanadate
7.1 Interactions of Hydroxamidovanadates with Heteroligands
7.2 Vanadium NMR Spectroscopy of Hydroxamido Complexes
References............. ..........................129
Chapter 8 Reactions of Oligovanadates... 131
8.1 The Smaller Oligomers... ............131
8.2 Decavanadate..... ................134
References............. ........................136
Chapter 9 Influence of Ligand Properties on Product Structure
and Reactivity
9.1 Alkyl Alcohols ........ ......139
9.2 Glycols, α-Hydroxy Acids, and Oxalate .......... 142
9.3 Bisperoxo and Bishydroxamido Vanadates: Heteroligand Reactivity ........144
9.4 henols
9.5 Diethanolamines........ .147
9.6 Pattern of Reactivity
References.... ............150
Chapter 10 Vanadium in Biological Systems
10.1 Distribution in the Environment .. 153
10.2 Vanadium-Ligand Complexes.... ....155
10.2.1 Amavadine............ ...........156
10.3 Vanadium Transport and Binding Proteins......... ........157
10.3.1 Vanabins .......... ..................159
10.4 Vanadium-Containing Enzymes........... ............160
10.4.1 Nitrogenases ................ .................160
10.4.2 Vanadium-Dependent Haloperoxidases .... 160
10.4.2.1 Haloperoxidase Active Site ..............................................162
10.4.2.2 Haloperoxidase Model Compounds .... .......163
References................ ...............................166
Chapter 11 The Influence of Vanadium Compounds on Biological Systems
11.1 Vanadium Compounds on Biological Systems: Cellular Growth,
Oxidation-Reduction Pathways, and Enzymes
11.1.1 Vanadium Compounds and Oxidation-Reduction Reactions
11.1.1.1 Vanadium-Dependent NADH Oxidation Activity............173
11.1.1.2 Vanadium Compounds and Cellular Oxidation-Reduction
Metabolism .... .174
11.1.2 Inhibition of Phosphate-Metabolizing Enzymes by Vanadium
Compounds
11.1.2.1 Inhibition of Ribonuclease
11.1.2.2 Inhibition of Protein Tyrosine Phosphatase 9
11.1.3 Effect of Vanadium Compounds on Growth and Development 11.1.4 Nutrition and Toxicology of Vanadium Vanadium
11.2.1 Vanadium as a Therapeutic Agent for Diabetes: Overview 4
11.2.1.1 Vanadium Compounds Used for Treatment of
Diabetes: Salts, Chelate Complexes, and
Peroxovanadium Compounds 186
11.2.1.2 Effects of Vanadium Compounds in Biological
Models... .187
11.2.2 Vanadium as Therapeutic Agent for Cancer
11.3 Mechanism of Therapeutic and Apoptotic Effects of Vanadium
11.3.1 Cellular Oxidation-Reduction Reactions as Part of the
Therapeutic Effect of Vanadium ... 193
11.3.2 Vanadium Interaction with Signal Transduction Cascades
as Part of the Therapeutic Effect .. ..194
11.4 Summary ...... ......199
Abbreviations ..... ....200
References....... ..........202
Chapter 12 Technological Development...... ..215
12.1 Molecular Networks and Nanomaterials ..... ..215
12.2 The Vanadium Redox Battery.. ....217
12.3 The Silver Vanadium Oxide Battery...... ...219
References..... ...........220
Chapter 13 Preparation, Characterization, and Battery Applications
of Silver Vanadium Oxide Materials
13.1 Introduction ........ ....221
13.2 Preparation, Structure, and Reactivity of Silver Vanadium Oxide and
Related Materials ..... ..221
13.3 Battery Applications of Silver Vanadium Oxide
13.3.1 Primary Silver Vanadium Oxide Cells.... 230
13.3.2 Rechargeable Silver Vanadium Oxide Cells
13.4 Summary ........ ..239
References.......... ......240
Index 245
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