Vol 452|27 March 2008| doi:10.1038/nature06740
标题：Proline-catalysed Mannich reactions of acetaldehyde
在2000年发现甫胺酸催化Mannich（J. Am.Chem. Soc. 122, 9336–9337 (2000).）反应以来，已经广泛的应用在合成的各个领域，如天然产物全合成，药物合成等等。自从发现Proline能高效高选择性催化一系列的反应以来，这一分子一直都是有机合成领域的明星分子。
Highly enantioselective prolinecatalysed Mannich reactions of acetaldehyde with N-Boc-imines.
These are the first examples of proline-catalysed cross-Mannich reactions with aliphatic unbranched imine acceptors.
The value of highly enantioselective acetaldehyde Mannich reaction, several useful transformations of product 3a have been devised
The reaction is exceptionally enantioselective and the products are of high value for multiple synthetic applications
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